Human ID & Forensics Human ID

Human ID Advanced Workflow Solutions for Paternity Testing

Direct amplification STR assays for use with collection cards or swabs are the primary solutions for routine paternity testing. For more challenging samples or complex cases, a comprehensive workflow including DNA purification and amplification is recommended.

Tackle even the most difficult cases by combining our superior sample collection and sample preparation solutions with reliable, high-quality marker sets including autosomal and X- and Y-chromosomal STR kits.

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Sample collection, automation and STR solutions for kinship testing

Streamline your paternity and kinship testing workflow

Autosomal STRs are in worldwide use for kinship and forensic analysis. The extended CODIS set has brought powerful upgrades to the battery of core markers available, but there are scenarios where supplementary STRs could enhance the kinship data. That’s why QIAGEN has a broad portfolio of supplementary kits for all types of kinship analyses. To complement these kits, QIAGEN offers support for sample collection, as well as nucleic acid purification technology specifically developed for human identification testing and a suite of automation solutions for both sample prep and assay setup. Trust QIAGEN expertise for your paternity testing applications.

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Advanced workflows for kinship testing

Highly discriminating STR profiles with Investigator 26plex QS Kit

Highly discriminating STR profiles with Investigator 26plex QS Kit

Gain highest mean exclusion chance

The basis of any paternity test is a full STR profile. The Investigator 26plex QS Kit is QIAGEN’s most discriminating STR marker set, and provides convenient paternity testing with the highest mean exclusion chance due to the choice of markers. You can use this assay for direct amplification from reference samples or amplification from purified DNA — it is optimized for both, without any compromise.

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X-chromosomal lineage tracing with Investigator Argus X-12 QS Kit

Resolve complex kinship and deficiency cases

In some cases, normal autosomal STR analysis is not enough to solve a case, particularly in deficiency cases where one parent is unavailable for testing. In these instances, X-chromosome genotyping can complement the analysis of autosomal and Y-chromosome markers very efficiently. The Investigator Argus X-12 QS Kit is the only commercially available kit that allows X-chromosomal STR analysis, a powerful aid in special X-chromosomal lineage tracing.

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X-chromosomal lineage tracing with Investigator Argus X-12 QS Kit

Y-STR haplotype analysis: Argus Y-28

Y-STR haplotype analysis with Investigator Argus Y-28 QS Kit

Resolve male offspring paternity disputes

Y-STR haplotype analysis is well established in resolving paternity disputes of male offspring and other types of paternal kinship testing, including historical cases. The Investigator Argus Y-28 QS Kit is designed for optimal performance and unparalleled discrimination. In particular, the inclusion of six rapidly mutating Y-STRs supports the resolution of paternal lineages and discriminates between closely related males. Obtain trusted results for challenging samples in less time.

Coming soon — the new Investigator Argus Y-28 QS Kit.

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Supplementary marker set with Investigator HDplex Kit

Boost your discrimination power in complex cases

Investigator HDplex is a supplementary marker set with novel, highly discriminating STR markers not found in other commercially available STR kits. When this kit is used to supplement the results obtained from a traditional STR kit, it enables unparalleled levels of discrimination for closely related individuals in highly complex kinship cases.

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Mixed profile analysis with Investigator HDplex Kit

High-throughput punching and assay setup with STAR Q Punch AS

High-throughput punching and assay setup with STAR Q Punch AS

Optimize your collection card workflow

Do you need a full collection card workflow solution from a single provider, and peace of mind? Standardize sample collection with the EasiCollect Plus for simple and inexpensive storage and transport at room temperature. Automate assay setup on the STAR Q Punch AS for preparation of up to 360 samples for PCR each day by a single operator. The Investigator 24plex GO! Kit ensures high success rates for database samples. An integrated Quality Sensor helps identify the cause of a failed PCR run and allows you to focus your resources on the most promising of your DNA samples.


High-throughput assay setup with STAR Q Swab AS

Optimize your buccal swab workflow

See how you can achieve reproducible, high-quality DNA profiles from your buccal swab workflow. Combine QIAGEN OmniSwabs or other buccal swabs with the Investigator 24plex GO! Kit on the STAR Q Swab AS for a high-throughput, automated solution for forensic reference samples. High performance is achieved while maintaining the stringent quality standards expected from QIAGEN Investigator solutions. Protocols are pre-defined and validated making implementation of the STAR Q Swab AS faster and easier than other liquid handling platforms.

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High-throughput assay setup with STAR Q Swab AS

Take your pre-natal testing to new levels with QIAGEN genomics

Non-invasive prenatal testing using UMI-based QIAseq targeted sequencing panel

Increase confidence in paternity calling more safely and cost-effectively

Prenatal genetic testing using invasive methods has an associated risk of miscarriage and infection. Non-invasive methods involve the safer approach of sampling maternal blood for circulating fetal cell free DNA (cfDNA). However, the fragmented nature and low copy number of cfDNA, combined with the resulting mixture of maternal and fetal DNA profiles, make STR analysis unfeasible. Single nucleotide polymorphisms (SNPs) require much smaller DNA amplicons and have proven effective for paternity testing from cfDNA. This new application refines the SNP/cfDNA strategy further by using much smaller numbers of SNPs and barcoding them with Unique Molecular Indices (UMIs) as part of a QIAseq targeted sequencing panel, bringing significantly greater accuracy to the final sequencing data.

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QIAGEN can help your forensic laboratory standardize sample processing, and enable you to achieve consistent high-quality results – from Sample to Insight, and for workflows not limited to paternity and kinship testing. Get more accurate information faster, whether you are a smaller lab with limited resources or a higher-throughput facility.


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