The emergence of global viral infections reminds us of the significant public health issues brought about by these pathogens. In the last 30 years, new viral threats have arisen across the world, as exemplified by the recent COVID-19 pandemic. Among these viral agents are two flaviviruses, West Nile Virus and Dengue Virus, and two coronaviruses, SARS-COV-1 and SARS-CoV-2. These viruses have had extensive impacts on human populations, and in many cases, have caused severe symptoms and even death. Therefore, understanding the immune response to these viruses is critical. We have analyzed the transcriptomes of cell lines infected by these viruses, to highlight differences in the short-term (<36 hours) impact on host gene responses.
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Jean-Noel Billaud, Ph.D., is Senior Principal Scientist at QIAGEN Bioinformatics. Before joining QIAGEN Bioinformatics, Dr. Billaud joined Ingenuity Systems in 2008 as staff scientist for in silico research program in oncology and infectious diseases. Jean-Noel Billaud holds a Ph.D. in Blood Cell Biology from Paris VII and has done his postdoctoral work at the Scripps Research Institute (San Diego, CA) studying the impact of Feline Immunodeficiency Virus and Borna Disease Virus on brain cells. He pursued his career at the Vaccine Research Institute of San Diego, where he co-developed a universal vaccine platform using the core antigen of Hepatitis B Virus to target infectious (viral and parasitic) diseases and metabolic diseases and cancer.
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